Poleman Nigel Mansell , the only driver ever to lap the 4.023 km (2.5 mi) Detroit circuit in under 1:40 during qualifying, led the race until his stop for tyres, but soon after began to fall away with cramp in his right leg making it hard to push the brake pedal. He later said that he had almost retired due to the pain but managed to finish in 5th place, one lap down on Senna.
Prost tried to convince McLaren via the radio that his tyres were OK and he did not need to stop, but he gave in to orders and pitted for fresh tyres. It was there that Goodyear technicians discovered Prost was correct and he had not needed to stop, though this did not alter the call for Piquet to stop as Prost had a reputation of being easier on his tyres than most.
Senna's back-to-back victories gave him a two-point lead in the championship over Prost, but it would be a brief surge. Senna would not win again this year. It would also be the last win in the very long history of Team Lotus which began with their first win in the 1961 United States Grand Prix . The next occasion on which a car bearing the Lotus name would win a Grand Prix was the 2012 Abu Dhabi Grand Prix , won by Kimi Räikkönen driving for the Lotus F1 team.